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The same caution applies to other compounds discussed in the context of mitochondrial protection, including matrine, pinocembrin, -lipoic acid, and related pleiotropic agents: although they may improve mitochondrial performance and attenuate ER stress, inflammation, or redox imbalance, they should be regarded primarily as broad stress-response modulators rather than selective regulators of organelle contact sites

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Int J Mol Sci 19(12):3894 Johnson AC, Li Z, Orfila JE, Herson PS, Cipolla MJ (2021) Hippocampal network dysfunction as a mechanism of early-onset dementia after preeclampsia and eclampsia